Diagnostic Green | ICG Indications


fluorescein
Source: ICG FLuorescence ophthalmology, Prof. Leys, UZ Leuven, Belgium

Ophthalmic diagnostics

In ophthalmic angiography the ICG is used for diagnostic purposes to examine the perfusion of the choroid and the retina. The performance devices for this application are ophthalmoscopes with an ICG fluorescence module provided for example, by Heidelberg Engineering and Zeiss. Through the visualization of the blood vessels of the eye ground disease such as Age-Related Macula Degeneration (AMD) and Diabetic Retinopathy can be diagnosed and the progression of the disease can be observed. Thus the information can be used to plan and control the success of therapy in order to minimize further damage to the tissue.

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Neurology
Source: Johann Wolfgang Goethe University, Frankfurt, Germany

Cerebral diagnostics

In cerebral pefusion diagnostics the ICG is used to visualize the blood flow in and around a brain (cerebral) aneurysm. The use of ICG is the gold standard for clipping procedures for aneurysm treatment. Intraoperatively, Indocyanine Green can be used to visualize the blood flow in the aneurysm to make sure that after the clipping, it is completely separated from blood flow in the vessel, and that surrounding vessels have not been compromised due to the clipping. The performance devices for this application are microscopes with an ICG fluorescence module, such as Zeiss and Leica.

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Source: Pulsion Medical Systems

Liver diagnostics

Because ICG is eliminated solely through the liver and there is no reabsorption in the gut, the removal of ICG from the circulation can be used to measure liver function and blood flow. In patients with normal liver function, the half-life of ICG in the circulation is 3-4 minutes. If the liver function is disturbed through disease, then the ICG is removed at a much slower rate.

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figure3
Breast reconstruction, Dr. Dornseifer, Klinikum Bogenhausen, Munich, Germany

Circulatory diagnostics

In plastic surgery, ICG can be used to visualize the blood flow (perfusion) in skin and muscle flaps. The evalution of the tissue perfusion is very important for the flap survival.

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